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Messenger RNA (mRNA)-based therapeutic agents have demonstrated significant potential in recent times, particularly in the context of the COVID-19 pandemic outbreak. As a promising prophylactic and therapeutic strategy, polypeptide-based mRNA...

Changes in background zonal wind in the tropical Pacific are often invoked to explain changes in ENSO properties. However, the sensitivity of ENSO to mean zonal winds has been thoroughly explored only in intermediate coupled models (following Zebiak and Cane), not in coupled GCMs. The role of mean meridional winds has received even less attention. Accordingly, the goal of this study is to examine systematically the effects of both zonal (equatorial) and meridional (cross-equatorial) background winds on ENSO using targeted experiments with a comprehensive climate model (CESM). Changes in the mean winds are generated by imposing heat flux forcing in two confined regions at a sufficient distance north and south of the equator. We find that the strengthening of either wind component reduces ENSO amplitude, especially eastern Pacific SST variability, and inhibits meridional swings of the intertropical convergence zone (ITCZ). The effect of zonal winds is generally stronger than that of meridional winds. A stability analysis reveals that the strengthening of zonal and meridional winds weakens the ENSO key positive feedbacks, specifically the zonal advection and thermocline feedbacks, which explains these changes. Zonal wind enhancement also intensifies mean upwelling and hence dynamical damping, leading to a further weakening of El Niño events. Ultimately, this study argues that the zonal and, to a lesser extent, meridional wind strengthening of the past decades may have contributed to the observed shift of El Niño characteristics after the year 2000.